Subventricular zone neural progenitors protect striatal neurons from glutamatergic excitotoxicity
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چکیده
منابع مشابه
Subventricular zone neural progenitors protect striatal neurons from glutamatergic excitotoxicity.
The functional significance of adult neural stem and progenitor cells in hippocampal-dependent learning and memory has been well documented. Although adult neural stem and progenitor cells in the subventricular zone are known to migrate to, maintain and reorganize the olfactory bulb, it is less clear whether they are functionally required for other processes. Using a conditional transgenic mous...
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Subventricular zone neural progenitors protect striatal neurons from glutamatergic excitotoxicity Erica Butti,* Marco Bacigaluppi,* Silvia Rossi, Marco Cambiaghi, Monica Bari, Arantxa Cebrian Silla, Elena Brambilla, Alessandra Musella, Roberta De Ceglia, Luis Teneud, Valentina De Chiara, Patrizia D’Adamo, Jose Manuel Garcia-Verdugo, Giancarlo Comi, Luca Muzio, Angelo Quattrini, Letizia Leocani,...
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Cannabinoid receptor agonists act presynaptically to inhibit the release of glutamate. Because other drugs with this action are known to reduce excitotoxicity, we tested several cannabimimetics in a model of synaptically mediated neuronal death. Reduction of the extracellular Mg2+ concentration to 0.1 mM evoked a repetitive pattern of intracellular Ca2+ concentration ([Ca2+]i) spiking that, whe...
متن کاملGABAergic striatal neurons project dendrites and axons into the postnatal subventricular zone leading to calcium activity
GABA regulates the behavior of neuroblasts and neural progenitor cells in the postnatal neurogenic subventricular zone (SVZ) through GABAA receptor (GABAAR)-mediated calcium increases. However, the source of GABA necessary for sufficient GABAAR-mediated depolarization and calcium increase has remained speculative. Here, we explored whether GABAergic striatal neurons functionally connect with SV...
متن کاملSubventricular zone progenitors in time and space: generating neuronal diversity
The adult mammalian brain harbors a population of cells around their lateral ventricles capable of giving rise to new neurons throughout life. The so-called subventricular zone (SVZ) is a heterogeneous germinative niche in regard to the neuronal types it generates. SVZ progenitors give rise to different olfactory bulb (OB) interneuron types in accordance to their position along the ventricles. ...
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ژورنال
عنوان ژورنال: Brain
سال: 2012
ISSN: 1460-2156,0006-8950
DOI: 10.1093/brain/aws194